Day 5: Immunology Lecture Part 1 Copy

Outline for Lymphoid Structures Rapid Course:
1. Immune system organs and lymph nodes
2. Lymphoid drainage associations
3. Spleen
4. Thymus

1. Innate versus Adaptive Immunity
2. Major Histocompatibility Complex I and II and HLA subtypes associated with diseases
3. Lymphocytes
4. T and B cell Activation

3. Anergy, Passive and Active Immunity
4. Vaccination
a. Live Attenuated
b. Killed
c. Subunit and Toxoid
d. Complications and Contraindications
5. Hypersensitivity Types
a. Type I
b. Type II
c. Type III
d. Type IV

8. Immunodeficiencies
a. X-linked agammaglobulinemia
b. Selective IgA deficiency
c. Common variable immunodeficiency
d. Thymic aplasia
e. IL-12 receptor deficiency
f. Autosomal dominant hyper-IgE syndrome
g. Chronic mucocutaneous candidiasis
h. Severe combined immunodeficiency
i. Ataxia-telangiectasia
j. Hyper-IgM syndrome
k. Wiscott-Aldrich syndrome
l. Leukocyte adhesion deficiency
m. Chedlak-Higashi syndrome
n. Chronic granulomatous disease

1. Immunosuppressants
a. Calcineurin inhibitors (cyclosporine and tacrolimus)
b. Sirolimus and rapamycin
c. Azathioprine
d. Mycophenolate Mofetil
2. Recombinant Cytokines:
a. Bone marrow stimulators: erythropoietin, colony stimulating factors and
thrombopoietin
b. Immunotherapy: interleukin-2 and interferons
3. Therapeutic antibodies:
a. Cancer therapy
b. Autoimmune disease therapy